A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN

The methionine 1 (M1)-specific deubiquitinase (DUB) OTULIN acts as a negative regulator of nuclear factor κB signaling and immune homeostasis. By replacing Gly76 in distal ubiquitin (Ub) by dehydroalanine we designed the diubiquitin (diUb) activity-based probe Ub(G76Dha)-Ub (OTULIN activity-based pr...

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Udgivet i:Cell Chem Biol
Main Authors: Weber, Aurelia, Elliott, Paul R., Pinto-Fernandez, Adan, Bonham, Sarah, Kessler, Benedikt M., Komander, David, El Oualid, Farid, Krappmann, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658516/
https://ncbi.nlm.nih.gov/pubmed/28919039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.08.006
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