Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension

Renovascular hypertension (RVH) has deleterious effects on both the kidney and the heart. TGF-β signaling through Smad3 directs tissue fibrosis in chronic injury models. In the 2-kidney 1-clip (2K1C) model of RVH, employing mice on the 129 genetic background, Smad3 deficiency (KO) protects the steno...

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Publicat a:PLoS One
Autors principals: Kashyap, Sonu, Warner, Gina, Hu, Zeng, Gao, Feng, Osman, Mazen, Al Saiegh, Yousif, Lien, Karen R., Nath, Karl, Grande, Joseph P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658153/
https://ncbi.nlm.nih.gov/pubmed/29073282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187062
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