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Exploring the Development of Ground-State Destabilization and Transition-State Stabilization in Two Directed Evolution Paths of Kemp Eliminases

Computer-aided enzyme design presents a major challenge since in most cases it has not resulted in an impressive catalytic power. The reasons for the problems with computational design include the use of nonquantitative approaches, but they may also reflect other difficulties that are not completely...

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Bibliografski detalji
Izdano u:ACS Catal
Glavni autori: Jindal, Garima, Ramachandran, Balajee, Bora, Ram Prasad, Warshel, Arieh
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658032/
https://ncbi.nlm.nih.gov/pubmed/29082065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.7b00171
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