Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (“shedding”) of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking o...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Cavadas, Miguel, Oikonomidi, Ioanna, Gaspar, Catarina J., Burbridge, Emma, Badenes, Marina, Félix, Inês, Bolado, Alfonso, Hu, Tianyi, Bileck, Andrea, Gerner, Christopher, Domingos, Pedro M., von Kriegsheim, Alex, Adrain, Colin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656746/
https://ncbi.nlm.nih.gov/pubmed/29045841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.074
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