Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (“shedding”) of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking o...

Full description

Saved in:
Bibliographic Details
Published in:Cell Rep
Main Authors: Cavadas, Miguel, Oikonomidi, Ioanna, Gaspar, Catarina J., Burbridge, Emma, Badenes, Marina, Félix, Inês, Bolado, Alfonso, Hu, Tianyi, Bileck, Andrea, Gerner, Christopher, Domingos, Pedro M., von Kriegsheim, Alex, Adrain, Colin
Format: Artigo
Language:Inglês
Published: Cell Press 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656746/
https://ncbi.nlm.nih.gov/pubmed/29045841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.074
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items