Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways. RNF145 expression is induced in response to LXR activati...

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Pubblicato in:eLife
Autori principali: Zhang, Li, Rajbhandari, Prashant, Priest, Christina, Sandhu, Jaspreet, Wu, Xiaohui, Temel, Ryan, Castrillo, Antonio, de Aguiar Vallim, Thomas Q, Sallam, Tamer, Tontonoz, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656429/
https://ncbi.nlm.nih.gov/pubmed/29068315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28766
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