Feedback modulation of cholesterol metabolism by LeXis, a lipid-responsive non-coding RNA

The liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. In the setting of cholesterol excess, LXR activation induces the expression of a battery of genes involved in cholesterol efflux (1), facilities cholesterol esterification by promoting fatty...

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Bibliographic Details
Published in:Nature
Main Authors: Sallam, Tamer, Jones, Marius, Gilliland, Thomas, Zhang, Li, Wu, Xiaohui, Eskin, Ascia, Sandhu, Jaspreet, Casero, David, de Aguiar Vallim, Thomas, Hong, Cynthia, Katz, Melanie, Lee, Richard, Whitelegge, Julian, Tontonoz, Peter
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896091/
https://ncbi.nlm.nih.gov/pubmed/27251289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17674
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