Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways. RNF145 expression is induced in response to LXR activati...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Principais autores: Zhang, Li, Rajbhandari, Prashant, Priest, Christina, Sandhu, Jaspreet, Wu, Xiaohui, Temel, Ryan, Castrillo, Antonio, de Aguiar Vallim, Thomas Q, Sallam, Tamer, Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656429/
https://ncbi.nlm.nih.gov/pubmed/29068315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28766
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados