Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase

Cholesterol biosynthesis is tightly regulated in the cell. For example, high sterol concentrations can stimulate degradation of the rate-limiting cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase, HMGCR). HMGCR is broken down by the endoplasmic reticu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jiang, Lu-Yi, Jiang, Wei, Tian, Na, Xiong, Yan-Ni, Liu, Jie, Wei, Jian, Wu, Kai-Yue, Luo, Jie, Shi, Xiong-Jie, Song, Bao-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857978/
https://ncbi.nlm.nih.gov/pubmed/29374057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001260
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