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Ubiquitination of STING at lysine 224 controls IRF3 activation()

Cytosolic DNA species derived from invading microbes or leaked from the nuclear or mitochondrial compartments of the cell can trigger the induction of host defense genes by activating the endoplasmic reticulum (ER)-associated protein STING. Using a mass spectrometry based approach, we show that afte...

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Bibliografski detalji
Izdano u:Sci Immunol
Glavni autori: Ni, Guoxin, Konno, Hiroyasu, Barber, Glen N.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656267/
https://ncbi.nlm.nih.gov/pubmed/28763789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aah7119
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