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Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA-Damage Responses and Correlates With Tumorigenesis

STING (stimulator of interferon genes) has been shown to be critical for controlling anti-viral responses, as well as anti-tumor adaptive immunity but little is known regarding its regulation in human tumors. Here, we report that STING-signaling is recurrently suppressed in a wide variety of cancers...

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Библиографические подробности
Опубликовано в: :Cell Rep
Главные авторы: Xia, Tianli, Konno, Hiroyasu, Ahn, Jeonghyun, Barber, Glen N.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845097/
https://ncbi.nlm.nih.gov/pubmed/26748708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.029
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