Adenine causes cell cycle arrest and autophagy of chronic myelogenous leukemia K562 cells via AMP-activated protein kinase signaling

AMP-activated protein kinase (AMPK) is known as a pivotal regulator of cellular metabolism. Mounting evidences have demonstrated that AMPK activation exerts tumor suppressive activity on leukemia cells. The present study reported that adenine, an AMPK activator, triggers cell cycle arrest and autoph...

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Publicado en:Oncol Lett
Main Authors: Chen, San-Yuan, Lin, Chun-Hsiang, Lin, Jiun-Tsai, Cheng, Yi-Fang, Chen, Han-Min, Kao, Shao-Hsuan
Formato: Artigo
Idioma:Inglês
Publicado: D.A. Spandidos 2017
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656030/
https://ncbi.nlm.nih.gov/pubmed/29113185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.6890
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