Csk-associated adaptor PAG inhibits effector T cell activation in cooperation with phosphatase PTPN22 and Dok adaptors

Transmembrane adaptor PAG (Cbp) has been proposed to mediate membrane recruitment of Csk, a cytoplasmic protein tyrosine kinase playing a critical inhibitory role during T cell activation, by inactivating membrane-associated Src kinases. However, this model has not been validated by genetic evidence...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Davidson, Dominique, Zhong, Ming-Chao, Pandolfi, Pier Paolo, Bolland, Silvia, Xavier, Ramnik J., Seed, Brian, Li, Xin, Gu, Hua, Veillette, André
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656005/
https://ncbi.nlm.nih.gov/pubmed/27926878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.035
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