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Peptide-level interactions between proteins and small-molecule drug candidates by two hydrogen-deuterium exchange MS-based methods: the example of ApoE3
We describe a platform utilizing two methods based on hydrogen–deuterium exchange (HDX) coupled with mass spectrometry (MS) to characterize interactions between a protein and a small-molecule ligand. The model system is apolipoprotein E3 (apoE3) and a small-molecule drug candidate. We extended PLIMS...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5655995/ https://ncbi.nlm.nih.gov/pubmed/28901129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b01121 |
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