Expansion of BCR/ABL1 (+) cells requires PAK2 but not PAK1

The p21‐activated kinases (PAKs) are key nodes in oncogenic signalling pathways controlling growth, survival, and motility of cancer cells. Their activity is increased in many human cancers and is associated with poor prognosis. To date, PAK deregulation has mainly been studied in solid tumours, whe...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Edlinger, Leo, Berger‐Becvar, Angelika, Menzl, Ingeborg, Hoermann, Gregor, Greiner, Georg, Grundschober, Eva, Bago‐Horvath, Zsuzsanna, Al‐Zoughbi, Wael, Hoefler, Gerald, Brostjan, Christine, Gille, Lars, Moriggl, Richard, Spittler, Andreas, Sexl, Veronika, Hoelbl‐Kovacic, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Haematological Malignancy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655792/
https://ncbi.nlm.nih.gov/pubmed/28707321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14833
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