PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis

The transcription factor STAT5 (signal transducer and activator of transcription 5) is frequently activated in hematological malignancies and represents an essential signaling node downstream of the BCR-ABL oncogene. STAT5 can be phosphorylated at three positions, on a tyrosine and on the two serine...

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Détails bibliographiques
Auteurs principaux: Berger, A, Hoelbl-Kovacic, A, Bourgeais, J, Hoefling, L, Warsch, W, Grundschober, E, Uras, I Z, Menzl, I, Putz, E M, Hoermann, G, Schuster, C, Fajmann, S, Leitner, E, Kubicek, S, Moriggl, R, Gouilleux, F, Sexl, V
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948164/
https://ncbi.nlm.nih.gov/pubmed/24263804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.351
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