C-terminal phosphorylation of Na(V)1.5 impairs FGF13-dependent regulation of channel inactivation

Voltage-gated Na(+) (Na(V)) channels are key regulators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in Na(V)1.5 channel inactivation are emerging as a critical determinant of arrhythmias in heart failure. However, the global native pho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Burel, Sophie, Coyan, Fabien C., Lorenzini, Maxime, Meyer, Matthew R., Lichti, Cheryl F., Brown, Joan H., Loussouarn, Gildas, Charpentier, Flavien, Nerbonne, Jeanne M., Townsend, R. Reid, Maier, Lars S., Marionneau, Céline
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655519/
https://ncbi.nlm.nih.gov/pubmed/28882890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.787788
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