Atomic-resolution map of the interactions between an amyloid inhibitor protein and amyloid β (Aβ) peptides in the monomer and protofibril states

Self-association of amyloid β (Aβ) peptides is a hallmark of Alzheimer's disease and serves as a general prototype for amyloid formation. A key endogenous inhibitor of Aβ self-association is human serum albumin (HSA), which binds ∼90% of plasma Aβ. However, the exact molecular mechanism by whic...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Algamal, Moustafa, Ahmed, Rashik, Jafari, Naeimeh, Ahsan, Bilal, Ortega, Joaquin, Melacini, Giuseppe
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Molecular Biophysics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655496/
https://ncbi.nlm.nih.gov/pubmed/28798235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792853
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