Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice

Lipid lowering properties of glucagon have been reported. Blocking glucagon signaling leads to rise in plasma LDL levels. Here, we demonstrate the lipid lowering effects of acute dosing with Glp1r/Gcgr dual agonist (DualAG). All the experiments were performed in 25 week-old male diet-induced (60% kC...

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Publicat a:PLoS One
Autors principals: More, Vijay R., Lao, Julie, McLaren, David G., Cumiskey, Anne-Marie, Murphy, Beth Ann, Chen, Ying, Previs, Stephen, Stout, Steven, Patel, Rajesh, Satapati, Santhosh, Li, Wenyu, Kowalik, Edward, Szeto, Daphne, Nawrocki, Andrea, Pocai, Alessandro, Wang, Liangsu, Carrington, Paul
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655430/
https://ncbi.nlm.nih.gov/pubmed/29065174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186586
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