Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice

Lipid lowering properties of glucagon have been reported. Blocking glucagon signaling leads to rise in plasma LDL levels. Here, we demonstrate the lipid lowering effects of acute dosing with Glp1r/Gcgr dual agonist (DualAG). All the experiments were performed in 25 week-old male diet-induced (60% kC...

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Pubblicato in:PLoS One
Autori principali: More, Vijay R., Lao, Julie, McLaren, David G., Cumiskey, Anne-Marie, Murphy, Beth Ann, Chen, Ying, Previs, Stephen, Stout, Steven, Patel, Rajesh, Satapati, Santhosh, Li, Wenyu, Kowalik, Edward, Szeto, Daphne, Nawrocki, Andrea, Pocai, Alessandro, Wang, Liangsu, Carrington, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655430/
https://ncbi.nlm.nih.gov/pubmed/29065174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186586
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