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HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer

We have shown that WT-161, a histone deacetylase 6 (HDAC6) inhibitor, shows remarkable anti-tumor activity in multiple myeloma (MM) in preclinical models. However, its activity in other type of cancers has not yet been shown. In this study, we further evaluated the biologic sequelae of WT161 in brea...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hideshima, Teru, Mazitschek, Ralph, Qi, Jun, Mimura, Naoya, Tseng, Jen-Chieh, Kung, Andrew L., Bradner, James E., Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655183/
https://ncbi.nlm.nih.gov/pubmed/29113288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19019
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