Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded proteins by the proteasome inhibitor bortezomib (BTZ) achieves responses and prolongs survival in MM, but long-term treatment w...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Hideshima, Teru, Qi, Jun, Paranal, Ronald M., Tang, Weiping, Greenberg, Edward, West, Nathan, Colling, Meaghan E., Estiu, Guillermina, Mazitschek, Ralph, Perry, Jennifer A., Ohguchi, Hiroto, Cottini, Francesca, Mimura, Naoya, Görgün, Güllü, Tai, Yu-Tzu, Richardson, Paul G., Carrasco, Ruben D., Wiest, Olaf, Schreiber, Stuart L., Anderson, Kenneth C., Bradner, James E.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2016
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135369/
https://ncbi.nlm.nih.gov/pubmed/27799547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608067113
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