Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded proteins by the proteasome inhibitor bortezomib (BTZ) achieves responses and prolongs survival in MM, but long-term treatment w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hideshima, Teru, Qi, Jun, Paranal, Ronald M., Tang, Weiping, Greenberg, Edward, West, Nathan, Colling, Meaghan E., Estiu, Guillermina, Mazitschek, Ralph, Perry, Jennifer A., Ohguchi, Hiroto, Cottini, Francesca, Mimura, Naoya, Görgün, Güllü, Tai, Yu-Tzu, Richardson, Paul G., Carrasco, Ruben D., Wiest, Olaf, Schreiber, Stuart L., Anderson, Kenneth C., Bradner, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135369/
https://ncbi.nlm.nih.gov/pubmed/27799547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608067113
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