Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death characterized by simultaneous activation of multiple cell death pathways preferentially killing transformed and cancer stem cells. We now show these si/shRNAs kill cancer cells through can...

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Vydáno v:eLife
Hlavní autoři: Putzbach, William, Gao, Quan Q, Patel, Monal, van Dongen, Stijn, Haluck-Kangas, Ashley, Sarshad, Aishe A, Bartom, Elizabeth T, Kim, Kwang-Youn A, Scholtens, Denise M, Hafner, Markus, Zhao, Jonathan C, Murmann, Andrea E, Peter, Marcus E
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655136/
https://ncbi.nlm.nih.gov/pubmed/29063830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29702
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