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Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering

Monoclonal antibodies of the immunoglobulin G (IgG) type have become mainstream therapeutics for the treatment of many life‐threatening diseases. For their successful application in the clinic and a favorable cost‐benefit ratio, the design and formulation of these therapeutic molecules must guarante...

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Bibliographische Detailangaben
Veröffentlicht in:Protein Sci
Hauptverfasser: Nemergut, Michal, Žoldák, Gabriel, Schaefer, Jonas V., Kast, Florian, Miškovský, Pavol, Plückthun, Andreas, Sedlák, Erik
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654860/
https://ncbi.nlm.nih.gov/pubmed/28833802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3278
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