Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells

CpG islands (CGIs) are primarily promoter-associated genomic regions and are mostly unmethylated within highly methylated mammalian genomes. The mechanisms by which CGIs are protected from de novo methylation remain elusive. Here we show that insertion of CpG-free DNA into targeted CGIs induces de n...

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Veröffentlicht in:Science
Hauptverfasser: Takahashi, Yuta, Wu, Jun, Suzuki, Keiichiro, Martinez-Redondo, Paloma, Li, Mo, Liao, Hsin-Kai, Wu, Min-Zu, Hernández-Benítez, Reyna, Hishida, Tomoaki, Shokhirev, Maxim Nikolaievich, Esteban, Concepcion Rodriguez, Sancho-Martinez, Ignacio, Belmonte, Juan Carlos Izpisua
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654639/
https://ncbi.nlm.nih.gov/pubmed/28473583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag3260
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