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Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells
CpG islands (CGIs) are primarily promoter-associated genomic regions and are mostly unmethylated within highly methylated mammalian genomes. The mechanisms by which CGIs are protected from de novo methylation remain elusive. Here we show that insertion of CpG-free DNA into targeted CGIs induces de n...
Shranjeno v:
| izdano v: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5654639/ https://ncbi.nlm.nih.gov/pubmed/28473583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag3260 |
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