Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells

CpG islands (CGIs) are primarily promoter-associated genomic regions and are mostly unmethylated within highly methylated mammalian genomes. The mechanisms by which CGIs are protected from de novo methylation remain elusive. Here we show that insertion of CpG-free DNA into targeted CGIs induces de n...

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Pubblicato in:Science
Autori principali: Takahashi, Yuta, Wu, Jun, Suzuki, Keiichiro, Martinez-Redondo, Paloma, Li, Mo, Liao, Hsin-Kai, Wu, Min-Zu, Hernández-Benítez, Reyna, Hishida, Tomoaki, Shokhirev, Maxim Nikolaievich, Esteban, Concepcion Rodriguez, Sancho-Martinez, Ignacio, Belmonte, Juan Carlos Izpisua
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654639/
https://ncbi.nlm.nih.gov/pubmed/28473583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag3260
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