Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Urinary tract infections (UTI) caused by uropathogenic E. coli (UPEC) affect 150 million people annually(1,2). Despite effective antibiotic therapy, 30–50% of patients experience recurrent UTI (rUTI)(1). Additionally, the growing prevelance of UPEC resistant to last-line antibiotic treatments, and m...

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Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Spaulding, Caitlin N., Klein, Roger D., Ruer, Ségolène, Kau, Andrew L., Schreiber, Henry L., Cusumano, Zachary T., Dodson, Karen W., Pinkner, Jerome S., Fremont, Daved H., Janetka, James W., Remaut, Han, Gordon, Jeffrey I., Hultgren, Scott J.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654549/
https://ncbi.nlm.nih.gov/pubmed/28614296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22972
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