In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases

GH29 α-l-fucosidases catalyze the hydrolysis of α-l-fucosidic linkages. Deficiency in human lysosomal α-l-fucosidase (FUCA1) leads to the recessively inherited disorder, fucosidosis. Herein we describe the development of fucopyranose-configured cyclophellitol aziridines as activity-based probes (ABP...

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Foilsithe in:Chem Sci
Main Authors: Jiang, Jianbing, Kallemeijn, Wouter W., Wright, Daniel W., van den Nieuwendijk, Adrianus M. C. H., Rohde, Veronica Coco, Folch, Elisa Colomina, van den Elst, Hans, Florea, Bogdan I., Scheij, Saskia, Donker-Koopman, Wilma E., Verhoek, Marri, Li, Nan, Schürmann, Martin, Mink, Daniel, Boot, Rolf G., Codée, Jeroen D. C., van der Marel, Gijsbert A., Davies, Gideon J., Aerts, Johannes M. F. G., Overkleeft, Herman S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Royal Society of Chemistry 2015
Ábhair:
Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654414/
https://ncbi.nlm.nih.gov/pubmed/29142681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc03739a
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