Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

BACKGROUND: From earlier studies it is known that the APOE ε2/ε3/ε4 polymorphism modulates the concentrations of cerebrospinal fluid (CSF) beta-amyloid(1–42) (Aβ42) in patients with cognitive decline due to Alzheimer’s disease (AD), as well as in cognitively healthy controls. Here, in a large cohort...

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Bibliografske podrobnosti
izdano v:Alzheimers Res Ther
Main Authors: Lautner, Ronald, Insel, Philip S., Skillbäck, Tobias, Olsson, Bob, Landén, Mikael, Frisoni, Giovanni B., Herukka, Sanna-Kaisa, Hampel, Harald, Wallin, Anders, Minthon, Lennart, Hansson, Oskar, Blennow, Kaj, Mattsson, Niklas, Zetterberg, Henrik
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654097/
https://ncbi.nlm.nih.gov/pubmed/29061195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-017-0313-3
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