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Association Between Apolipoprotein E ε2 vs ε4, Age, and β-Amyloid in Adults Without Cognitive Impairment

IMPORTANCE: Although the most common recent approach in Alzheimer disease drug discovery is to directly target the β-amyloid (Aβ) pathway, the high prevalence of apolipoprotein E ε4 (APOE ε4) in Alzheimer disease and the ease of identifying ε4 carriers make the APOE genotype and its corresponding pr...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Insel, Philip S., Hansson, Oskar, Mattsson-Carlgren, Niklas
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7551211/
https://ncbi.nlm.nih.gov/pubmed/33044487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2020.3780
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