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TP53 alterations in Wilms tumour represent progression events with strong intratumour heterogeneity that are closely linked but not limited to anaplasia

TP53 mutations have been associated with anaplasia in Wilms tumour, which conveys a high risk for relapse and fatal outcome. Nevertheless, TP53 alterations have been reported in no more than 60% of anaplastic tumours, and recent data have suggested their presence in tumours that do not fulfil the cr...

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Bibliografski detalji
Izdano u:J Pathol Clin Res
Glavni autori: Wegert, Jenny, Vokuhl, Christian, Ziegler, Barbara, Ernestus, Karen, Leuschner, Ivo, Furtwängler, Rhoikos, Graf, Norbert, Gessler, Manfred
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653929/
https://ncbi.nlm.nih.gov/pubmed/29085664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cjp2.77
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