CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease

In Alzheimer’s disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanis...

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Publicat a:Sci Rep
Autors principals: Koch, Giacomo, Di Lorenzo, Francesco, Loizzo, Stefano, Motta, Caterina, Travaglione, Sara, Baiula, Monica, Rimondini, Roberto, Ponzo, Viviana, Bonnì, Sonia, Toniolo, Sofia, Sallustio, Fabrizio, Bozzali, Marco, Caltagirone, Carlo, Campana, Gabriele, Martorana, Alessandro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653826/
https://ncbi.nlm.nih.gov/pubmed/29062035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14204-3
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