CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease

In Alzheimer’s disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanis...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Koch, Giacomo, Di Lorenzo, Francesco, Loizzo, Stefano, Motta, Caterina, Travaglione, Sara, Baiula, Monica, Rimondini, Roberto, Ponzo, Viviana, Bonnì, Sonia, Toniolo, Sofia, Sallustio, Fabrizio, Bozzali, Marco, Caltagirone, Carlo, Campana, Gabriele, Martorana, Alessandro
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653826/
https://ncbi.nlm.nih.gov/pubmed/29062035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14204-3
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