CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease

In Alzheimer’s disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanis...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koch, Giacomo, Di Lorenzo, Francesco, Loizzo, Stefano, Motta, Caterina, Travaglione, Sara, Baiula, Monica, Rimondini, Roberto, Ponzo, Viviana, Bonnì, Sonia, Toniolo, Sofia, Sallustio, Fabrizio, Bozzali, Marco, Caltagirone, Carlo, Campana, Gabriele, Martorana, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653826/
https://ncbi.nlm.nih.gov/pubmed/29062035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14204-3
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