CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease

In Alzheimer’s disease (AD) patients, apopoliprotein (APOE) polymorphism is the main genetic factor associated with more aggressive clinical course. However, the interaction between cerebrospinal fluid (CSF) tau protein levels and APOE genotype has been scarcely investigated. A possible key mechanis...

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Vydáno v:Sci Rep
Hlavní autoři: Koch, Giacomo, Di Lorenzo, Francesco, Loizzo, Stefano, Motta, Caterina, Travaglione, Sara, Baiula, Monica, Rimondini, Roberto, Ponzo, Viviana, Bonnì, Sonia, Toniolo, Sofia, Sallustio, Fabrizio, Bozzali, Marco, Caltagirone, Carlo, Campana, Gabriele, Martorana, Alessandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653826/
https://ncbi.nlm.nih.gov/pubmed/29062035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14204-3
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