Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of three liver-specific transcription factors between crosses of two inbred mouse strains to elucidate the regulatory mechanism...

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Udgivet i:Nat Commun
Main Authors: Wong, Emily S., Schmitt, Bianca M., Kazachenka, Anastasiya, Thybert, David, Redmond, Aisling, Connor, Frances, Rayner, Tim F., Feig, Christine, Ferguson-Smith, Anne C., Marioni, John C., Odom, Duncan T., Flicek, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653656/
https://ncbi.nlm.nih.gov/pubmed/29061983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01037-x
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