Evolution of AF6-RAS association and its implications in mixed-lineage leukemia

Elucidation of activation mechanisms governing protein fusions is essential for therapeutic development. MLL undergoes rearrangement with numerous partners, including a recurrent translocation fusing the epigenetic regulator to a cytoplasmic RAS effector, AF6/afadin. We show here that AF6 employs a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Smith, Matthew J., Ottoni, Elizabeth, Ishiyama, Noboru, Goudreault, Marilyn, Haman, André, Meyer, Claus, Tucholska, Monika, Gasmi-Seabrook, Genevieve, Menezes, Serena, Laister, Rob C., Minden, Mark D., Marschalek, Rolf, Gingras, Anne-Claude, Hoang, Trang, Ikura, Mitsuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653649/
https://ncbi.nlm.nih.gov/pubmed/29062045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01326-5
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