METFORMIN AMELIORATES GENDER- AND AGE-DEPENDENT HEMODYNAMIC INSTABILITY AND MYOCARDIAL INJURY IN MURINE HEMORRHAGIC SHOCK

Severity of multiple organ failure is significantly impacted by age and gender in patients with hemorrhagic shock. However, the molecular mechanisms underlying the enhanced organ injury are not fully understood. AMP-activated protein kinase (AMPK) is a pivotal orchestrator of metabolic responses dur...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Matsiukevich, Dzmitry, Piraino, Giovanna, Lahni, Patrick, Hake, Paul W., Wolfe, Vivian, O’Connor, Michael, James, Jeanne, Zingarelli, Basilia
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653443/
https://ncbi.nlm.nih.gov/pubmed/28579457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2017.05.027
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