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Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA

The development of new agents to target HBV cccDNA is urgently needed because of the limitations of current available drugs for treatment of hepatitis B. By using a cell-based assay in which the production of HBeAg is in a cccDNA-dependent manner, we screened a compound library derived from Chinese...

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Foilsithe in:Antiviral Res
Main Authors: Liu, Chunlan, Cai, Dawei, Zhang, Lin, Tang, Wei, Yan, Ran, Guo, Haitao, Chen, Xulin
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653380/
https://ncbi.nlm.nih.gov/pubmed/27591143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.08.026
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