Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA

The development of new agents to target HBV cccDNA is urgently needed because of the limitations of current available drugs for treatment of hepatitis B. By using a cell-based assay in which the production of HBeAg is in a cccDNA-dependent manner, we screened a compound library derived from Chinese...

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Bibliografiske detaljer
Udgivet i:Antiviral Res
Main Authors: Liu, Chunlan, Cai, Dawei, Zhang, Lin, Tang, Wei, Yan, Ran, Guo, Haitao, Chen, Xulin
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653380/
https://ncbi.nlm.nih.gov/pubmed/27591143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.08.026
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