Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant

We have previously engineered new RNase P-based ribozyme variants with improved in vitro catalytic activity. In this study, we employed a novel engineered variant to target a shared mRNA region of human cytomegalovirus (HCMV) immediate early proteins 1 (IE1) and 2 (IE2), which are essential for the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sun, Xu, Chen, Weijie, He, Lingling, Sheng, Jingxue, Liu, Yujun, Vu, Gia-Phong, Yang, Zhu, Li, Wei, Trang, Phong, Wang, Yu, Hai, Rong, Zhu, Hua, Lu, Sangwei, Liu, Fenyong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653336/
https://ncbi.nlm.nih.gov/pubmed/29059242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186791
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