Lactate stimulates CA IX expression in normoxic cancer cells

Besides hypoxia, other factors and molecules such as lactate, succinate, and reactive oxygen species activate transcription factor hypoxia-inducible factor-1 (HIF-1) even in normoxia. One of the main target gene products of HIF-1 is carbonic anhydrase IX (CA IX). CA IX is overexpressed in many tumor...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Panisova, Elena, Kery, Martin, Sedlakova, Olga, Brisson, Lucie, Debreova, Michaela, Sboarina, Martina, Sonveaux, Pierre, Pastorekova, Silvia, Svastova, Eliska
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652817/
https://ncbi.nlm.nih.gov/pubmed/29100428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20836
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