DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt’s lymphoma

Aberrant DNA methylation is a hallmark of cancer. However, our understanding of how tumor cell-specific DNA methylation patterns are established and maintained is limited. Here, we report that in T-cell acute lymphoblastic leukemia (T-ALL) and Burkitt’s lymphoma the MYC oncogene causes overexpressio...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Poole, Candace J., Zheng, Wenli, Lodh, Atul, Yevtodiyenko, Aleksey, Liefwalker, Daniel, Li, Honglin, Felsher, Dean W., van Riggelen, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652751/
https://ncbi.nlm.nih.gov/pubmed/29100357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20176
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