Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma

The tuberous sclerosis complex (TSC) 1/2 is a negative regulator of the nutrient‐sensing kinase mechanistic target of rapamycin complex (mTORC1), and its function is generally associated with tumor suppression. Nevertheless, biallelic loss of function of TSC1 or TSC2 is rarely found in malignant tum...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Hartleben, Götz, Müller, Christine, Krämer, Andreas, Schimmel, Heiko, Zidek, Laura M, Dornblut, Carsten, Winkler, René, Eichwald, Sabrina, Kortman, Gertrud, Kosan, Christian, Kluiver, Joost, Petersen, Iver, van den Berg, Anke, Wang, Zhao‐Qi, Calkhoven, Cornelis F
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213278/
https://ncbi.nlm.nih.gov/pubmed/30237309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798589
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