Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice

The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptations in response to changes in nutrient supply. Major downstream targets of mTORC1 signalling are the mRNA translation regulators p70 ribosomal protein S6 kinase 1 (S6K1p70) and the 4E-binding protein...

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Gepubliceerd in:EMBO Rep
Hoofdauteurs: Zidek, Laura M, Ackermann, Tobias, Hartleben, Götz, Eichwald, Sabrina, Kortman, Gertrud, Kiehntopf, Michael, Leutz, Achim, Sonenberg, Nahum, Wang, Zhao-Qi, von Maltzahn, Julia, Müller, Christine, Calkhoven, Cornelis F
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Ltd 2015
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552494/
https://ncbi.nlm.nih.gov/pubmed/26113365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439837
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