Analytic validation and real-time clinical application of an amplicon-based targeted gene panel for advanced cancer

Multiplex somatic testing has emerged as a strategy to test patients with advanced cancer. We demonstrate our analytic validation approach for a gene hotspot panel and real-time prospective clinical application for any cancer type. The TruSight Tumor 26 assay amplifies 85 somatic hotspot regions acr...

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Publicat a:Oncotarget
Autors principals: Wing, Michele R., Reeser, Julie W., Smith, Amy M., Reeder, Matthew, Martin, Dorrelyn, Jewell, Benjamin M., Datta, Jharna, Miya, Jharna, Monk, J. Paul, Mortazavi, Amir, Otterson, Gregory A., Goldberg, Richard M., VanDeusen, Jeffrey B., Cole, Sharon, Dittmar, Kristin, Jaiswal, Sunny, Kinzie, Matthew, Waikhom, Suraj, Freud, Aharon G., Zhou, Xiao-Ping, Chen, Wei, Bhatt, Darshna, Roychowdhury, Sameek
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652665/
https://ncbi.nlm.nih.gov/pubmed/29100271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20616
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