Evaluation of Hybridization Capture Versus Amplicon‐Based Methods for Whole‐Exome Sequencing

Next‐generation sequencing has aided characterization of genomic variation. While whole‐genome sequencing may capture all possible mutations, whole‐exome sequencing remains cost‐effective and captures most phenotype‐altering mutations. Initial strategies for exome enrichment utilized a hybridization...

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Bibliographic Details
Published in:Hum Mutat
Main Authors: Samorodnitsky, Eric, Jewell, Benjamin M., Hagopian, Raffi, Miya, Jharna, Wing, Michele R., Lyon, Ezra, Damodaran, Senthilkumar, Bhatt, Darshna, Reeser, Julie W., Datta, Jharna, Roychowdhury, Sameek
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
Subjects:
Methods
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832303/
https://ncbi.nlm.nih.gov/pubmed/26110913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22825
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