Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398

Activation of fibroblast growth factor receptor (FGFR) signaling through mutations, amplifications, or fusions involving FGFR1, 2, 3, or 4 are seen in multiple tumors including lung, bladder, and cholangiocarcinoma. Currently, several clinical trials are evaluating the role of novel FGFR inhibitors...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Datta, Jharna, Damodaran, Senthilkumar, Parks, Hannah, Ocrainiciuc, Cristina, Miya, Jharna, Yu, Lianbo, Gardner, Elijah P., Samorodnitsky, Eric, Wing, Michele R., Bhatt, Darshna, Hays, John, Reeser, Julie W., Roychowdhury, Sameek
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539948/
https://ncbi.nlm.nih.gov/pubmed/28255027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-1010
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