Evaluation of Hybridization Capture Versus Amplicon‐Based Methods for Whole‐Exome Sequencing

Next‐generation sequencing has aided characterization of genomic variation. While whole‐genome sequencing may capture all possible mutations, whole‐exome sequencing remains cost‐effective and captures most phenotype‐altering mutations. Initial strategies for exome enrichment utilized a hybridization...

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Vydáno v:Hum Mutat
Hlavní autoři: Samorodnitsky, Eric, Jewell, Benjamin M., Hagopian, Raffi, Miya, Jharna, Wing, Michele R., Lyon, Ezra, Damodaran, Senthilkumar, Bhatt, Darshna, Reeser, Julie W., Datta, Jharna, Roychowdhury, Sameek
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Methods
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832303/
https://ncbi.nlm.nih.gov/pubmed/26110913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22825
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