Analytic validation and real-time clinical application of an amplicon-based targeted gene panel for advanced cancer

Multiplex somatic testing has emerged as a strategy to test patients with advanced cancer. We demonstrate our analytic validation approach for a gene hotspot panel and real-time prospective clinical application for any cancer type. The TruSight Tumor 26 assay amplifies 85 somatic hotspot regions acr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wing, Michele R., Reeser, Julie W., Smith, Amy M., Reeder, Matthew, Martin, Dorrelyn, Jewell, Benjamin M., Datta, Jharna, Miya, Jharna, Monk, J. Paul, Mortazavi, Amir, Otterson, Gregory A., Goldberg, Richard M., VanDeusen, Jeffrey B., Cole, Sharon, Dittmar, Kristin, Jaiswal, Sunny, Kinzie, Matthew, Waikhom, Suraj, Freud, Aharon G., Zhou, Xiao-Ping, Chen, Wei, Bhatt, Darshna, Roychowdhury, Sameek
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652665/
https://ncbi.nlm.nih.gov/pubmed/29100271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20616
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